基本情況
朱茂碧，女，海南人，中共黨員，江門(mén)市二級(jí)人才。現(xiàn)任五邑大學(xué)藥學(xué)與食品工程學(xué)院專(zhuān)任教師。主持五邑大學(xué)五邑大學(xué)高層次人才科研啟動(dòng)經(jīng)費(fèi)、省市級(jí)項(xiàng)目共計(jì)3項(xiàng)，在研總經(jīng)費(fèi)超過(guò)100萬(wàn)。參與國(guó)家自然科學(xué)基金面上項(xiàng)目、重點(diǎn)研發(fā)項(xiàng)目、廣東省教育廳創(chuàng)新團(tuán)隊(duì)及重點(diǎn)領(lǐng)域?qū)ｍ?xiàng)等若干項(xiàng)。已發(fā)表SCI論文十多篇，其中第一作者及通訊作者文章5篇。目前依托華南生物醫(yī)藥大動(dòng)物模型研究院及廣東省醫(yī)學(xué)大動(dòng)物重點(diǎn)實(shí)驗(yàn)室開(kāi)展研究工作，研究方向?yàn)槔酶杉?xì)胞及類(lèi)器官技術(shù)研究婦產(chǎn)科相關(guān)疾病發(fā)生機(jī)制，生殖健康、基因編輯動(dòng)物模型的建立等。
聯(lián)系方式
地址：廣東省江門(mén)市蓬江區(qū)東成村22號(hào) 五邑大學(xué)藥學(xué)與食品工程學(xué)院
郵編：529020
郵箱：[email protected]
工作經(jīng)歷
2020年7月至今，五邑大學(xué)，藥學(xué)與食品工程學(xué)院，碩士生導(dǎo)師
教育及學(xué)習(xí)經(jīng)歷
2016年4月-2020年3月 日本國(guó)立山梨大學(xué)，醫(yī)學(xué)工學(xué)綜合研究部，博士
2012年9月-2015年6月 廈門(mén)大學(xué)，醫(yī)學(xué)院，碩士
2006年9月-2011年7月 廈門(mén)大學(xué)，醫(yī)學(xué)院，學(xué)士
主要研究方向
利用干細(xì)胞及類(lèi)器官技術(shù)研究婦產(chǎn)科相關(guān)疾病發(fā)生機(jī)制，生殖健康、基因編輯動(dòng)物模型的建立等
發(fā)表學(xué)術(shù)論文
1. Chen, Y.; Zhang, S.; Sun, Y.; Zou, J.; Qiu, X.; Xi, H.; Xu, Y.; Li, Y.; Chen, B.; Fan, J.; Zhu, M. Bisphenol A impairs oocyte maturation by dysfunction of cumulus cells. Theriogenology 2025, 233, 139-146, doi:10.1016/j.theriogenology.2024.11.023. （通訊作者）
2. Wang, N.; Yang, H.; Chen, Y.; Wang, H.; Wang, C.; Fan, J.; Chen, Y.; Li, Y.; Zhu, M. Formononetin promotes porcine oocytes maturation and improves embryonic development by reducing oxidative stress. Front Cell Dev Biol 2024, 12, 1520429, doi:10.3389/fcell.2024.1520429. （通訊作者）
3. Zhu, M.; Wang, N.; Wang, S.; Wang, Y.; Yang, X.; Fan, J.; Chen, Y. Effects of Follicular Fluid on Physiological Characteristics and Differentiation of Fallopian Tube Epithelial Cells Implicating for Ovarian Cancer Pathogenesis. Int. J. Mol. Sci. 2023, 24, 10154.
4. Zhu, M., S. Takeda, and T. Iwano, Natural Herbal Estrogen-Mimetics (Phytoestrogens) Promote the Differentiation of Fallopian Tube Epithelium into Multi-Ciliated Cells via Estrogen Receptor Beta. Molecules, 2021. 26(3).
5. Zhu, M.; Iwano, T.; Takeda, S. Fallopian Tube Basal Stem Cells Reproducing the Epithelial Sheets In Vitro—Stem Cell of Fallopian Epithelium. Biomolecules 2020, 10, 1270.
6. Zhu, M., Iwano, T., and Takeda, S. (2019). Estrogen and EGFR Pathways Regulate Notch Signaling in Opposing Directions for Multi-Ciliogenesis in the Fallopian Tube. Cells 2019, 8, 933.
7. Dai, S., Zhu, M., Wu, R., Lin, D., Huang, Z., Ren, L., Huang, S., Cheng, L., and Chen, Q. (2019). Lipoxin A4 Suppresses IL-1beta-Induced Cyclooxygenase-2 Expression Through Inhibition of p38 MAPK Activation in Endometriosis. Reprod Sci, 1933719119828115. (Co-first author)
8. Wang, J.; Li, Y.-H.; Liu, R.-P.; Wang, X.-Q.; Zhu, M.-B.; Cui, X.-S.; Dai, Z.; Kim, N.-H.; Xu, Y.-N. Supplementation with Eupatilin during In Vitro Maturation Improves Porcine Oocyte Developmental Competence by Regulating Oxidative Stress and Endoplasmic Reticulum Stress. Animals 2024, 14, 449.
9. Chen, Y., X. Yang, S. Kitajima, L. Quan, Y. Wang, M. Zhu, E. Liu, L. Lai, H. Yan and J. Fan, Macrophage elastase derived from adventitial macrophages modulates aortic remodeling. Front Cell Dev Biol, 2022. 10: p. 1097137.
10. Chen, Y., X. Yang, S. Kitajima, L. Quan, Y. Wang, M. Zhu, E. Liu, L. Lai, H. Yan and J. Fan, Macrophage elastase derived from adventitial macrophages modulates aortic remodeling. Front Cell Dev Biol, 2022. 10: p. 1097137.
11. Huang, Q., Chen, Y., Chen, Q., Zhang, H., Lin, Y., Zhu, M., and Dong, S. (2017). Dioxin-like rather than non-dioxin-like PCBs promote the development of endometriosis through stimulation of endocrine-inflammation interactions. Archives of toxicology 91, 1915-1924.
12. Chen, Y., Huang, Q., Chen, Q., Lin, Y., Sun, X., Zhang, H., Zhu, M., and Dong, S. (2015). The inflammation and estrogen metabolism impacts of polychlorinated biphenyls on endometrial cancer cells. Toxicology in vitro: an international journal published in association with BIBRA 29, 308-313.
13. Wu, R., Zhou, W., Chen, S., Shi, Y., Su, L., Zhu, M., and Chen, Q. (2014). Lipoxin A4 suppresses the development of endometriosis in an ALX receptor-dependent manner via the p38 MAPK pathway. British journal of pharmacology 171, 4927-4940.
14. Chen, S., Wu, R.F., Su, L., Zhou, W.D., Zhu, M.B., and Chen, Q.H. (2014). Lipoxin A4 regulates expression of the estrogen receptor and inhibits 17beta-estradiol induced p38 mitogen-activated protein kinase phosphorylation in human endometriotic stromal cells. Fertility and sterility 102, 264-271.
15. Shen, Y.T., Song, Y.Q., He, X.Q., Zhang, F., Huang, X., Liu, Y., Ding, L., Xu, L., Zhu, M.B., Hu, W.F., et al. (2014). Triphenyltin chloride induces spindle microtubule depolymerisation and inhibits meiotic maturation in mouse oocytes. Reprod Fertil Dev 26, 1084-1093.
16. Liu, Y., He, X.Q., Huang, X., Ding, L., Xu, L., Shen, Y.T., Zhang, F., Zhu, M.B., Xu, B.H., Qi, Z.Q., et al. (2013). Resveratrol protects mouse oocytes from methylglyoxal-induced oxidative damage. PLoS One 8, e77960.
參加學(xué)術(shù)會(huì)議及論文
(1) Estrogen promotes the fallopian tube epithelial multi-ciliogenesis through estrogen receptor β, Japan Society for Cell Biology,日本東京(會(huì)議報(bào)告)
(2) The Role of Estrogen and Notch Signal in Porcine Fallopian Tube Epithelium Differentiation,日本解剖學(xué)會(huì)年會(huì),日本東京(會(huì)議報(bào)告)
(3) Suppression of Notch signal by estrogen and EGFR pathway facilitates motile ciliogenesis in fallopian tube epithelial cells,日本纖毛學(xué)會(huì),日本山梨(會(huì)議報(bào)告)
(4) Estrogen regulates ciliogenesis through estrogen receptorβin porcine fallopian tube,日本解剖學(xué)會(huì)年會(huì),日本長(zhǎng)崎(會(huì)議報(bào)告)
申請(qǐng)及授權(quán)專(zhuān)利
1、一種體外豬來(lái)源的輸卵管上皮細(xì)胞類(lèi)組織培養(yǎng)方法，發(fā)明人：朱茂碧; 王娜; 王莎; 陳亞檞; 范江霖; 王瑤; 楊夏雯，申請(qǐng)?zhí)枺?02310019244.3，申請(qǐng)時(shí)間：2023年01月06日，授權(quán)單位：五邑大學(xué)，發(fā)明專(zhuān)利
2、一種促進(jìn)輸卵管上皮纖毛細(xì)胞形成的添加劑及其應(yīng)用，發(fā)明人：朱茂碧,王莎,王娜,襲昊曈,張雙,鄒家倫,范江霖,陳亞檞，申請(qǐng)?zhí)枺?02310412768.9，申請(qǐng)日：2023 年04 月17 日，授權(quán)單位：五邑大學(xué)，發(fā)明專(zhuān)利
3、一種誘導(dǎo)原代輸卵管上皮細(xì)胞定向分化為纖毛細(xì)胞的方法，發(fā)明人：朱茂碧,王莎,王娜,襲昊曈,張雙,鄒家倫,范江霖,陳亞檞，申請(qǐng)?zhí)枺?023104133073，申請(qǐng)日：2023 年04 月17 日，授權(quán)單位：五邑大學(xué)，發(fā)明專(zhuān)利
獲獎(jiǎng)及榮譽(yù)
2017-2020中國(guó)留學(xué)基金委公派留學(xué)獎(jiǎng)學(xué)金
